Mutation and expression analysis of LZTS1 in ovarian cancer

Jeremy M Arnold; David Y H Choong; John Lai; Ian G Campbell; Georgia Chenevix-Trench

doi:10.1016/j.canlet.2005.03.008

Mutation and expression analysis of LZTS1 in ovarian cancer

Cancer Lett. 2006 Feb 20;233(1):151-7. doi: 10.1016/j.canlet.2005.03.008.

Authors

Jeremy M Arnold¹, David Y H Choong, John Lai, Ian G Campbell, Georgia Chenevix-Trench

Affiliation

¹ Queensland Institute of Medical Research, P.O. Box Royal Brisbane Hospital, Herston, Qld 4029, Australia. jeremya@qimr.edu.au

PMID: 15876481
DOI: 10.1016/j.canlet.2005.03.008

Abstract

LZTS1 has been shown to have tumour suppressor activities against prostate and breast cancer and is located within a region of frequent loss of heterozygosity (LOH) at 8p22 in ovarian cancer. We have analysed the expression of LZTS1 in ovarian cancer and found no evidence of loss of expression relative to normal ovarian surface epithelial cells. We have also analysed the coding region of the LZTS1 gene in 87 primary ovarian adenocarcinomas by DHPLC and detected a single silent somatic mutation. These data indicate that LZTS1 is not the target of LOH at 8p22 in ovarian cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / genetics*
Cell Line, Tumor
Chromatography, High Pressure Liquid
DNA-Binding Proteins / genetics*
Female
Humans
Loss of Heterozygosity
Mutation*
Ovarian Neoplasms / genetics*
Ovary / metabolism
Polymorphism, Single Nucleotide
Tumor Suppressor Proteins / genetics*

Substances

DNA-Binding Proteins
LZTS1 protein, human
Tumor Suppressor Proteins