Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation

Transplant Proc. 2005 Mar;37(2):1385-7. doi: 10.1016/j.transproceed.2004.12.281.

Abstract

In contrast to solid organ transplantation, ABO incompatibility is generally not associated with survival differences in hematopoietic stem cell transplantation. Therefore, patients receiving ABO-incompatible stem cell transplantation can be analyzed to study the mechanism of tolerance induction after antigen-mismatched transplantation. The goal of this study was to analyze the levels of anti-A/B antibodies after ABO-incompatible transplantation. Host-derived antidonor antibodies disappeared rapidly after transplantation and did not reappear in the further posttransplant course. Donor-derived antihost antibodies did not significantly increase and compatible anti-A/B antibodies remained positive after hematopoietic stem cell transplantation. Thus, there is no evidence for stimulation of donor B lymphocytes to produce antirecipient antibodies suggesting a potential B cell tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / immunology*
  • Anemia, Aplastic / immunology
  • Anemia, Aplastic / therapy
  • Blood Group Incompatibility / etiology
  • Blood Group Incompatibility / immunology*
  • Erythrocytes / immunology
  • Graft vs Host Reaction / immunology
  • Hematologic Neoplasms / immunology
  • Hematologic Neoplasms / therapy
  • Host vs Graft Reaction / immunology
  • Humans
  • Stem Cell Transplantation / adverse effects*

Substances

  • ABO Blood-Group System