Abstract
We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Asbestos / poisoning*
-
Case-Control Studies
-
Cocarcinogenesis*
-
DNA, Neoplasm / genetics
-
Female
-
Humans
-
Male
-
Mesothelioma / epidemiology
-
Mesothelioma / etiology*
-
Mesothelioma / genetics
-
Mesothelioma / virology
-
Molecular Epidemiology
-
Polymerase Chain Reaction
-
Polyomavirus Infections / complications*
-
Polyomavirus Infections / virology
-
Simian virus 40 / genetics
-
Simian virus 40 / physiology*
-
Tumor Virus Infections / complications*
-
Tumor Virus Infections / virology
-
Urinary Bladder Neoplasms / epidemiology
-
Urinary Bladder Neoplasms / etiology
-
Urinary Bladder Neoplasms / genetics
-
Urinary Bladder Neoplasms / virology