Abstract
The pauciimmune small-vessel vasculitides are multisystem diseases with frequent renal involvement. They are strongly associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). In this review we have focused on the ethiopathogenesis and the role of ANCA, clinical presentation and histopathologic findings of different ANCA - associated vasculitides (AAV). Current treatment strategies and the overall and renal outcome of patients with AAV are also discussed.
MeSH terms
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Antibodies, Antineutrophil Cytoplasmic / analysis*
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Churg-Strauss Syndrome / diagnosis
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Churg-Strauss Syndrome / immunology
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Churg-Strauss Syndrome / therapy
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Granulomatosis with Polyangiitis / diagnosis
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Granulomatosis with Polyangiitis / immunology
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Granulomatosis with Polyangiitis / therapy
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Humans
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Kidney Diseases / diagnosis
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Kidney Diseases / immunology*
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Kidney Diseases / therapy
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Vasculitis / diagnosis
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Vasculitis / immunology*
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Vasculitis / therapy
Substances
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Antibodies, Antineutrophil Cytoplasmic