Lyophilised aqueous extract and alcaloidic totum (basic form) from roots of Tinospora bakis (Miers) have been tested with hyperthermic rabbits by sub-cutaneous administration of Saccharomyces cerevisiae mixture at 2g/kg. Total aqueous extract had been orally administrated at three doses: 150, 300 and 600 mg/kg and we obtained significant antipyretic effects at 300 and 600 mg/kg. With the alcaloidic totum at 2.5 mg/kg and 10 mg/kg (per os) corresponding to 150 and 600 mg/kg of the aqueous extract, we have observed significant antipyretic effects as compared with those of Aspirin used as reference product. These results show that aqueous extract of Tinospora bakis (Miers) has an antipyretic effect and total alcaloids could account for this activity.