Abstract
The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Aged
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Aged, 80 and over
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Aging / metabolism
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Aging / pathology
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Alzheimer Disease / pathology*
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Alzheimer Disease / physiopathology
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Amnesia / complications
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Amnesia / pathology*
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Amnesia / physiopathology
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Biomarkers
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Body Water / metabolism
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Cognition Disorders / complications
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Cognition Disorders / pathology*
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Cognition Disorders / physiopathology
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Diffusion
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Diffusion Magnetic Resonance Imaging
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Disease Progression
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Early Diagnosis
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Female
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Hippocampus / chemistry
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Hippocampus / pathology*
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Hippocampus / physiopathology
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Humans
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Male
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Multivariate Analysis
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Neuropsychological Tests
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Predictive Value of Tests
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Prognosis