Insulin therapy in people who have dysglycemia and type 2 diabetes mellitus: can it offer both cardiovascular protection and beta-cell preservation?

Hertzel C Gerstein; Julio Rosenstock

doi:10.1016/j.ecl.2004.11.002

Insulin therapy in people who have dysglycemia and type 2 diabetes mellitus: can it offer both cardiovascular protection and beta-cell preservation?

Endocrinol Metab Clin North Am. 2005 Mar;34(1):137-54. doi: 10.1016/j.ecl.2004.11.002.

Authors

Hertzel C Gerstein¹, Julio Rosenstock

Affiliation

¹ Division of Endocrinology and Metabolism and the Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON L8N 3Z5, Canada. gerstein@mcmaster.ca

PMID: 15752926
DOI: 10.1016/j.ecl.2004.11.002

Abstract

Mounting evidence suggests that insulin therapy may reduce risk for CV events while preserving beta-cell function, and several continuing long-term CV trials are testing these hypotheses explicitly.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cardiovascular Diseases / complications*
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / prevention & control*
Clinical Trials as Topic
Diabetes Mellitus, Type 2 / complications*
Diabetes Mellitus, Type 2 / metabolism
Diabetes Mellitus, Type 2 / therapy
Humans
Hyperglycemia / complications*
Hyperglycemia / drug therapy*
Hyperglycemia / metabolism
Insulin / therapeutic use*
Islets of Langerhans / metabolism*

Substances

Insulin