Antinociceptive diterpene from Euphorbia decipiens

Viqar Uddin Ahmad; Hidayat Hussain; Ishfaq A Bukhari; Javid Hussain; Amir Reza Jassbi; Ahsana Dar

doi:10.1016/j.fitote.2004.12.014

Antinociceptive diterpene from Euphorbia decipiens

Fitoterapia. 2005 Mar;76(2):230-2. doi: 10.1016/j.fitote.2004.12.014.

Authors

Viqar Uddin Ahmad¹, Hidayat Hussain, Ishfaq A Bukhari, Javid Hussain, Amir Reza Jassbi, Ahsana Dar

Affiliation

¹ HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

PMID: 15752637
DOI: 10.1016/j.fitote.2004.12.014

Abstract

One myrsinol-type diterpene ester (1) isolated from Euphorbia decipiens was evaluated for analgesic activity in the acetic acid induced writhing test in mice. Different dose (5-20 mg/kg i.p.) of the compound showed significant antinociceptive activity, which was comparable to standard analgesic drugs, aspirin and ibuprofen (100 mg/kg i.p.).

MeSH terms

Acetic Acid
Analgesics / administration & dosage
Analgesics / pharmacology*
Analgesics / therapeutic use
Animals
Diterpenes / administration & dosage
Diterpenes / pharmacology
Diterpenes / therapeutic use
Euphorbia*
Female
Male
Mice
Pain / chemically induced
Pain / prevention & control*
Pain Measurement / drug effects
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use

Substances

Analgesics
Diterpenes
Plant Extracts
Acetic Acid