QF-PCR examination of parental and meiotic origin of trisomy 21 in Central and Eastern Europe

J Histochem Cytochem. 2005 Mar;53(3):371-3. doi: 10.1369/jhc.4B6510.2005.

Abstract

Study of parental/meiotic origin of free trisomy 21 in nuclear families from Russia (70 cases), Ukraine (32 cases), and 22 from Germany revealed maternal nondisjunction in 77.3% (Germany), 93.8% (Ukraine), and 91.4% (Russia), paternal origin in 13.6%, 6.2%, and 8.6%, respectively. Maternal meiosis I errors were found in 84.4% (Ukraine), 77.1% (Russia), paternal origin in 3.1% (Ukraine), 2.9% (Russia). Maternal meiosis II errors occurred in 9.4% and 14.3% and paternal in 3.1% and 5.7% in Ukraine and Russia, respectively. No significant differences were found in maternal/paternal origin among Ukraine, Russia, Germany, and published data from other European regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Down Syndrome / epidemiology*
  • Down Syndrome / genetics*
  • Female
  • Fluorescence
  • Genomic Imprinting*
  • Germany / epidemiology
  • Humans
  • Male
  • Meiosis*
  • Nondisjunction, Genetic*
  • Parents
  • Polymerase Chain Reaction
  • Russia / epidemiology
  • Ukraine / epidemiology