1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11. doi: 10.1016/j.bmcl.2005.01.031.

Abstract

4-Sulfonyl analogs of 1-(1-naphthyl)piperazine bind at human 5-HT6 receptors and represent a novel class of human 5-HT6 receptor ligands.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ligands
  • Models, Chemical
  • Molecular Structure
  • Piperazines / chemistry*
  • Piperazines / pharmacology
  • Protein Binding
  • Receptors, Serotonin / metabolism*
  • Structure-Activity Relationship
  • Tryptamines / chemistry
  • Tryptamines / pharmacology

Substances

  • Ligands
  • N1-benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine
  • Piperazines
  • Receptors, Serotonin
  • Tryptamines
  • serotonin 6 receptor
  • 1-(1-naphthyl)piperazine