Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion

Neurosci Lett. 2005 Feb 21;374(3):189-91. doi: 10.1016/j.neulet.2004.10.053. Epub 2004 Nov 19.

Abstract

We recently reported here that SNCA triplication results in a doubling in the amount of alpha-synuclein protein in blood from cases with hereditary Lewy body disease. This observation shows that alpha-synuclein levels in blood accurately reflect gene dosage, which we assume drives pathogenesis in these individuals. A previous report has suggested that parkin can affect alpha-synuclein metabolism in human brain. Here we have tested whether there is also an increase of alpha-synuclein in autosomal recessive juvenile Parkinsonism (ARJP). We find there is not and discuss this result in terms of the putative relationships between alpha-synuclein and parkin.

Publication types

  • Comparative Study

MeSH terms

  • Blotting, Western / methods
  • Exons*
  • Family Health
  • Gene Deletion*
  • Gene Dosage
  • Humans
  • Nerve Tissue Proteins / blood*
  • Parkinsonian Disorders / blood
  • Parkinsonian Disorders / genetics*
  • Synucleins
  • Ubiquitin-Protein Ligases / genetics*
  • alpha-Synuclein

Substances

  • Nerve Tissue Proteins
  • SNCA protein, human
  • Synucleins
  • alpha-Synuclein
  • Ubiquitin-Protein Ligases
  • parkin protein