The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target

Br J Cancer. 2005 Jan 31;92(2):290-3. doi: 10.1038/sj.bjc.6602329.

Abstract

Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / genetics*
  • Female
  • Humans
  • Immunoblotting
  • Mice
  • Nuclear Proteins
  • Oncogene Proteins / genetics*
  • Oncogene Proteins, Viral / drug effects*
  • Papillomaviridae / genetics*
  • Proto-Oncogene Proteins
  • RNA, Small Interfering / therapeutic use*
  • Uterine Cervical Neoplasms / drug therapy*

Substances

  • Carrier Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Oncogene Proteins, Viral
  • Proto-Oncogene Proteins
  • RNA, Small Interfering
  • WAPL protein, human