Robustness of the no-interference model for ordering genetic markers

T P Speed; M S McPeek; S N Evans

doi:10.1073/pnas.89.7.3103

Robustness of the no-interference model for ordering genetic markers

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3103-6. doi: 10.1073/pnas.89.7.3103.

Authors

T P Speed¹, M S McPeek, S N Evans

Affiliation

¹ Department of Statistics, University of California, Berkeley 94720.

Abstract

Under the assumption of no chromatid interference, we derive constraints on the probabilities of the different recombination patterns among m + 1 genetic loci. An application of these constraints is a proof that the ordering of the loci that maximizes the likelihood under the assumption of no interference is, in fact, a consistent estimator of the true order even when there is interference.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chromatids / ultrastructure
Chromosome Mapping / methods
Genetic Linkage*
Likelihood Functions
Probability
Recombination, Genetic*