Objective: To study antiradiation effect of panaxatriol (PT) and to provide an experiment basis for developing relative radiation-resistant skin care products.
Methods: Mice were treated with PT or normal saline (the control group) before X-ray irradiation and were to observe the number of chromosme aberrations killed 3 hours after irradiation. The chromosome samples of bone marrow cells were prepared and chromatid mutation as well as aberrant cells.
Results: PT can reduce the frequency of chromatid mutative induced by X-ray. Antiradiation effect was positively correlated with the dose of PT and the duration of drug, and negatively correlated with the dose of X-rays.
Conclusion: PT has significant antiradiation effect.