Thermodynamics of interaction of phthalocyanine-oligonucleotide conjugates with single- and double-stranded DNA

A A Chernonosov; N A Kuznetsov; V V Koval; D V Pyshnyi; N M Derkacheva; E A Lukyanets; O S Fedorova

doi:10.1081/NCN-200026051

Thermodynamics of interaction of phthalocyanine-oligonucleotide conjugates with single- and double-stranded DNA

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(6-7):983-7. doi: 10.1081/NCN-200026051.

Authors

A A Chernonosov¹, N A Kuznetsov, V V Koval, D V Pyshnyi, N M Derkacheva, E A Lukyanets, O S Fedorova

Affiliation

¹ Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.

PMID: 15560090
DOI: 10.1081/NCN-200026051

Abstract

Thermodynamics of interaction of phthalocyanine-oligonucleotide conjugates with single- and double-stranded DNA resulting in formation of duplexes and triplexes was measured by UV melting method. It was shown that a phthalocyanine moiety of conjugates stabilized the formation of duplexes and triplexes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Circular Dichroism
DNA / chemistry*
DNA, Single-Stranded / chemistry*
Indoles / chemistry*
Isoindoles
Oligonucleotides / chemistry*
Thermodynamics
Ultraviolet Rays

Substances

DNA, Single-Stranded
Indoles
Isoindoles
Oligonucleotides
DNA
phthalocyanine