Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts

Genet Med. 2004 Nov-Dec;6(6):481-6. doi: 10.1097/01.gim.0000144012.18935.48.

Abstract

Purpose: Our aim was to test whether polymorphisms in the lipoprotein lipase (LPL) gene were associated with the progression of atherosclerosis in grafts examined in the Post-Coronary Artery Bypass Graft Trial (Post-CABG Trial).

Methods: 843 subjects in the post-CABG trial were genotyped for the LPL-D9N, N291S, PvuII, (TTTA)n, and HindIII polymorphisms. Associations between genotype and angiographically measured progression of atherosclerosis in grafts, medical history, and family history were examined.

Results: Greater progression of atherosclerosis was observed in subjects with LPL-HindIII 2/2 (56% versus 42% of those with other LPL HindIII genotypes, P = 0.025) and with LPL (TTTA)n 4/4 (63% versus 43% of those with other (TTTA)n genotypes, P = 0.020). Mantel-Haenszel analysis yielded an odds ratio of 1.84 for the effect of LPL HindIII 2/2 genotype on the progression of atherosclerosis in grafts (P = 0.015) and demonstrated that the effect of genotype on progression was of the same magnitude as, but independent of, the effect of drug treatment.

Conclusion: The LPL-HindIII 2/2 genotype is a marker for genetic variation in the 3'-end of LPL that acts as an independent risk factor for the progression of atherosclerosis in grafts examined in the Post-CABG Trial.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arteriosclerosis / drug therapy
  • Arteriosclerosis / genetics*
  • Arteriosclerosis / physiopathology
  • Cholestyramine Resin / therapeutic use
  • Coronary Angiography
  • Coronary Artery Bypass*
  • Deoxyribonuclease HindIII
  • Female
  • Genotype
  • Humans
  • Lipoprotein Lipase / genetics*
  • Lovastatin / therapeutic use
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*
  • Saphenous Vein / transplantation

Substances

  • Cholestyramine Resin
  • Lovastatin
  • Lipoprotein Lipase
  • Deoxyribonuclease HindIII