Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction

John G Ilagan; David M Stamilio; Serdar H Ural; George A Macones; Anthony O Odibo

doi:10.1016/j.ajog.2004.05.065

Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction

Am J Obstet Gynecol. 2004 Oct;191(4):1465-9. doi: 10.1016/j.ajog.2004.05.065.

Authors

John G Ilagan¹, David M Stamilio, Serdar H Ural, George A Macones, Anthony O Odibo

Affiliation

¹ Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA, USA.

PMID: 15507984
DOI: 10.1016/j.ajog.2004.05.065

Abstract

Objective: The purpose of this study was to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUGR) pregnancies.

Study design: This was a case control study of IUGR pregnancies (birth weight <10th percentile for gestational age [GA]) delivered in our unit over 6 years. Cases were compared with controls for the association between abnormal MMS and adverse perinatal outcomes (APO).

Results: Of the 261 IUGR pregnancies, 39 (16%) had at least 1 APO. An elevated HCG was significantly associated with an APO (OR 2.6, 95% CI 1.1-6.4). A low uE3 was also associated with an APO (OR 5.5, 95% CI 2.2-14). The association between an elevated AFP and APO was not statistically significant (OR 1.6, 95% CI, 0.6-4.6).

Conclusion: An elevated HCG and low uE3 were associated with APO in cases of IUGR. This information could be useful in identifying a subset of IUGR cases deserving closer surveillance.

MeSH terms

Case-Control Studies
Estriol / blood*
Female
Fetal Growth Retardation / blood*
Humans
Logistic Models
Pregnancy
Pregnancy Outcome*
ROC Curve
Sensitivity and Specificity
alpha-Fetoproteins / analysis*

Substances

alpha-Fetoproteins
Estriol