Objective: To investigate the influences of beta3 adrenergic receptor(beta3AR) Trp64Arg polymorphism on insulin resistance.
Methods: The insulin sensitivity was estimated with logarithm transformed homeostasis model assessment (HOMA). We enrolled 88 pairs of dizygotic twins for this study. We performed PCR-RFLP analysis to detect the Trp64Arg variants with BstO I digestion.
Results: The genotypic frequencies of Trp64Trp, Trp64Arg and Arg64Arg were 71.5%, 26.7% and 1.7%. Those who carried Trp64Arg variant appeared to have lower insulin sensitivity compared to the one who didn't, but had no significance(P=0.145). Body mass index (BMI) had shown to be weakly positive correlated with lgHOMA. We found no significant association between the Trp64Arg variant and BMI.
Conclusion: The presence of the Arg64 allele in beta3AR gene may predispose patients to insulin resistance, and further study with larger sample size may help to confirm the result.