Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis

Neurology. 2004 Sep 28;63(6):1084-6. doi: 10.1212/01.wnl.0000138493.04890.7c.

Abstract

The authors analyzed the female: male (F:M) ratio according to the HLA-DRB1-DQB1 genotype in a cohort of multiple sclerosis (MS) patients from Sardinia, where the disease is associated with DR3 and DR4. In the whole cohort of 1,097 patients, F:M ratio was 2.24; however, it was 2.88 in DR3/DR3 and 2.52 in DR3/DRX (X#DR3 and DR4) individuals. Parental transmission of DR3 and DR4, assessed in a set of 565 case-parent triads, showed evidence of paternal inheritance of DR3 in affected women, thus explaining the excess of females in the DR3 category.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosome Segregation*
  • Cohort Studies
  • Fathers
  • Female
  • Gene Frequency
  • Genes, MHC Class II*
  • Genetic Predisposition to Disease
  • HLA-DQ Antigens / genetics
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / genetics
  • HLA-DR3 Antigen / genetics*
  • HLA-DR4 Antigen / genetics
  • HLA-DRB1 Chains
  • Haplotypes / genetics
  • Humans
  • Italy / epidemiology
  • Logistic Models
  • Male
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology
  • Sex Distribution
  • Siblings

Substances

  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DR3 Antigen
  • HLA-DR4 Antigen
  • HLA-DRB1 Chains