Transient appearance of lactate dehydrogenase (LDH)-linked immunoglobulin and thyroid dysfunction at the postpartum period

Intern Med. 2004 Jul;43(7):575-7. doi: 10.2169/internalmedicine.43.575.

Abstract

Here, we report a 28-year-old woman who transiently showed lactate dehydrogenase (LDH)-linked immunoglobulin during postpartum thyroiditis. She demonstrated high levels of serum LDH (794 IU/l) and thyroid hormones 7 months after delivery. Electrophoretic isoenzyme analysis of LDH showed an abnormal broadband caused by LDH-linked immunoglobulin (IgG-kappa). Transient thyrotoxicosis due to postpartum thyroiditis improved without any specific treatment, and elevated serum concentration of LDH decreased to the normal level (395 IU/l) with disappearance of LDH-linked IgG. LDH-linked immunoglobulin may also appear at the postpartum period.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Chemical Analysis
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulins, Thyroid-Stimulating / analysis
  • Immunoglobulins, Thyroid-Stimulating / immunology
  • Immunoglobulins, Thyroid-Stimulating / metabolism*
  • L-Lactate Dehydrogenase / immunology*
  • L-Lactate Dehydrogenase / metabolism
  • Postpartum Period
  • Pregnancy
  • Remission, Spontaneous
  • Risk Assessment
  • Severity of Illness Index
  • Thyroid Function Tests
  • Thyroiditis, Autoimmune / diagnosis*

Substances

  • Immunoglobulins, Thyroid-Stimulating
  • L-Lactate Dehydrogenase