Abstract
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bacterial Proteins / genetics*
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Bites and Stings
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Borrelia burgdorferi / growth & development*
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Borrelia burgdorferi / pathogenicity*
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Borrelia burgdorferi / physiology
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Carbon-Sulfur Lyases
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Female
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Ixodes / microbiology*
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Lyme Disease / microbiology
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Lyme Disease / pathology
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Lyme Disease / transmission*
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Mice
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Mice, Inbred C3H
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Mutation
Substances
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Bacterial Proteins
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Carbon-Sulfur Lyases
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LuxS protein, Bacteria