Breast biopsy recommendations are commonly made on the basis of mammographic findings. Benign breast biopsies secondary to false positive mammographic interpretation remain a major source of discussion. A review of recent series of biopsy results is presented and the factors influencing positive predictive value are discussed. Methods to improve mammographic specificity, including validity of certain mammographic signs such as mass density are summarized. Issues relating to lesions followed on mammography--including number of views, compliance, and patient anxiety--are also addressed.