Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with linezolid

Matteo Bassetti; Antonio Di Biagio; Valerio Del Bono; Giovanni Cenderello; Dante Bassetti

doi:10.1016/j.ijantimicag.2003.12.018

Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with linezolid

Int J Antimicrob Agents. 2004 Jul;24(1):83-4. doi: 10.1016/j.ijantimicag.2003.12.018.

Authors

Matteo Bassetti¹, Antonio Di Biagio, Valerio Del Bono, Giovanni Cenderello, Dante Bassetti

Affiliation

¹ Department of Infectious Diseases, San Martino Hospital, University of Genoa, School of Medicine, Genoa, Italy.

PMID: 15225867
DOI: 10.1016/j.ijantimicag.2003.12.018

Abstract

We report the successful treatment with linezolid of a methicillin-resistant Staphylococcus aureus (MRSA) endocarditis in a patient with a severe allergic reaction to glycopeptides. Linezolid is a drug with well-recognised activity against S. aureus and proved to be efficacious even in the unusual site of heart valves. This drug could be a good therapeutic choice when glycopeptides treatment is not feasible.

MeSH terms

Acetamides / therapeutic use*
Anti-Infective Agents / therapeutic use*
Endocarditis, Bacterial / drug therapy*
Endocarditis, Bacterial / microbiology
Humans
Linezolid
Methicillin Resistance*
Oxazolidinones / therapeutic use*
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
Staphylococcus aureus / isolation & purification

Substances

Acetamides
Anti-Infective Agents
Oxazolidinones
Linezolid