Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5. doi: 10.1073/pnas.0402644101. Epub 2004 May 26.

Abstract

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen Presentation*
  • Cell Movement
  • Dendritic Cells / classification
  • Dendritic Cells / immunology*
  • Dendritic Cells / pathology
  • Herpes Simplex / immunology
  • Herpes Simplex / pathology
  • Herpesvirus 1, Human
  • Histocompatibility Antigens Class I / metabolism
  • In Vitro Techniques
  • Lung Diseases / immunology*
  • Lung Diseases / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Orthomyxoviridae Infections / immunology
  • Orthomyxoviridae Infections / pathology
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Histocompatibility Antigens Class I