Purpose of review: This article provides an overview of randomized studies of altered fractionated radiotherapy (RT) in Head and Neck squamous cell carcinoma.
Recent findings: Both hyperfractionated RT and accelerated RT may improve tumor control probability as compared to conventional RT, along with increased but manageable toxicity and a modest improvement in survival.
Summary: Altered RT is a tool that can improve the results obtained with conventional RT in Head and squamous cell carcinoma.