The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

Peptides. 2004 Jan;25(1):81-9. doi: 10.1016/j.peptides.2003.12.008.

Abstract

The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bothrops jararaca Venom
  • Calgranulin B / chemistry*
  • Calgranulin B / therapeutic use
  • Crotalid Venoms*
  • Edema / chemically induced
  • Edema / drug therapy*
  • Hyperalgesia / chemically induced
  • Hyperalgesia / drug therapy*
  • Male
  • Metalloendopeptidases*
  • Mice / metabolism*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Calgranulin B
  • Crotalid Venoms
  • Platelet Aggregation Inhibitors
  • Metalloendopeptidases