Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans

Analyst. 2004 Mar;129(3):259-64. doi: 10.1039/b314316n. Epub 2004 Jan 27.

Abstract

Metabonomic screening of human urine samples using 1H NMR spectroscopy has revealed the presence of signals resulting from the excretion of ethyl glucoside. Experiments in volunteers have demonstrated that this ethyl glucoside results from dietary exposure to the compound, which is present in beverages such as rice wine and sake, rather than representing a new route for the metabolism of ethanol by humans. The limited studies undertaken in volunteers indicate that ethyl glucoside has a longer biological half life than ethanol itself. The potential problems associated with using this glucoside metabolite as a marker of ethanol consumption are considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, High Pressure Liquid / methods
  • Diet
  • Female
  • Glucosides / administration & dosage
  • Glucosides / urine*
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Oryza
  • Wine

Substances

  • Glucosides
  • ethyl glucoside