Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses

Infect Immun. 2004 Mar;72(3):1828-31. doi: 10.1128/IAI.72.3.1828-1831.2004.

Abstract

While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

MeSH terms

  • Chemokines / biosynthesis*
  • Heterozygote
  • Humans
  • In Vitro Techniques
  • Inflammation Mediators / metabolism*
  • Interferon-gamma / biosynthesis
  • Interleukin-10 / biosynthesis
  • Interleukin-8 / biosynthesis
  • Lipopolysaccharides / pharmacology*
  • Membrane Glycoproteins / genetics*
  • Mutation, Missense
  • Polymorphism, Genetic*
  • Receptors, Cell Surface / genetics*
  • Teichoic Acids / pharmacology*
  • Toll-Like Receptor 2
  • Toll-Like Receptors
  • Transfection
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Chemokines
  • Inflammation Mediators
  • Interleukin-8
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • TLR2 protein, human
  • Teichoic Acids
  • Toll-Like Receptor 2
  • Toll-Like Receptors
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • lipoteichoic acid
  • Interferon-gamma