Pneumocandins from Zalerion arboricola. I. Discovery and isolation

J Antibiot (Tokyo). 1992 Dec;45(12):1853-66. doi: 10.7164/antibiotics.45.1853.

Abstract

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

MeSH terms

  • Anti-Bacterial Agents*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Biotransformation
  • Candida albicans / drug effects
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Echinocandins
  • Microbial Sensitivity Tests
  • Microbiological Techniques
  • Mitosporic Fungi / chemistry*
  • Mitosporic Fungi / metabolism
  • Peptides*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology
  • Pneumocystis / drug effects

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Echinocandins
  • Peptides
  • Peptides, Cyclic
  • pneumocandin A(0)
  • pneumocandin B(0)
  • pneumocandin C(0)