Two potential mechanisms of oxaliplatin-induced haemolytic anaemia in a single patient

Ralf-Dieter Hofheinz; Xuan-Duc Nguyen; Dieter Buchheidt; Mohammed Kerowgan; Rüdiger Hehlmann; Andreas Hochhaus

doi:10.1007/s00280-003-0731-8

Two potential mechanisms of oxaliplatin-induced haemolytic anaemia in a single patient

Cancer Chemother Pharmacol. 2004 Mar;53(3):276-7. doi: 10.1007/s00280-003-0731-8. Epub 2003 Dec 16.

Authors

Ralf-Dieter Hofheinz¹, Xuan-Duc Nguyen, Dieter Buchheidt, Mohammed Kerowgan, Rüdiger Hehlmann, Andreas Hochhaus

Affiliation

¹ III. Medical Clinic, University Hospital Mannheim, University of Heidelberg, Wiesbadener Strasse 7-11, 68167 Mannheim, Germany. ralf.hofheinz@med3.ma.uni-heidelberg.de

PMID: 14676977
DOI: 10.1007/s00280-003-0731-8

Abstract

Only two patients with adequately documented oxaliplatin-induced autoimmune haemolytic anaemia have previously been reported. We report here a third patient with an immune-haematological finding favouring a bispecific mechanism (immune-complex and penicillin type) of oxaliplatin-induced haemolysis.

Publication types

Case Reports

MeSH terms

Anemia, Hemolytic / chemically induced*
Anemia, Hemolytic / diagnosis
Anemia, Hemolytic / immunology
Antineoplastic Agents / adverse effects*
Autoimmune Diseases / chemically induced
Autoimmune Diseases / diagnosis
Autoimmune Diseases / immunology
Female
Humans
Middle Aged
Organoplatinum Compounds / adverse effects*
Oxaliplatin

Substances

Antineoplastic Agents
Organoplatinum Compounds
Oxaliplatin