Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA

Am J Cardiol. 2003 Dec 15;92(12):1492-4. doi: 10.1016/j.amjcard.2003.08.072.

Abstract

We report the incidence of aspirin nonresponsiveness in a prospective, multicenter registry (n=422 patients) to be 23% using the Ultegra Rapid Platelet Function Assay-ASA, and determined a history of coronary artery disease to be associated with twice the odds of being an aspirin nonresponder (odds ratio 2.01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events.

Publication types

  • Multicenter Study

MeSH terms

  • Aspirin / therapeutic use*
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / drug therapy*
  • Drug Resistance*
  • Female
  • Hematocrit
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Count
  • Platelet Function Tests / methods
  • Predictive Value of Tests
  • Prospective Studies
  • Registries

Substances

  • Platelet Aggregation Inhibitors
  • Aspirin