Enzyme-prodrug systems: carboxylesterase/CPT-11

Methods Mol Med. 2004:90:247-62. doi: 10.1385/1-59259-429-8:247.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacokinetics
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Antineoplastic Agents, Phytogenic / toxicity
  • Biotransformation
  • Camptothecin / analogs & derivatives*
  • Camptothecin / pharmacokinetics*
  • Camptothecin / therapeutic use
  • Camptothecin / toxicity
  • Carboxylesterase / chemistry
  • Carboxylesterase / genetics*
  • Carboxylesterase / metabolism*
  • Carboxylic Ester Hydrolases / genetics
  • Carboxylic Ester Hydrolases / metabolism
  • Genes, Transgenic, Suicide
  • Genetic Therapy / methods
  • Humans
  • Irinotecan
  • Liver / enzymology
  • Molecular Sequence Data
  • Neoplasms / drug therapy*
  • Prodrugs / pharmacokinetics*
  • Prodrugs / therapeutic use
  • Prodrugs / toxicity
  • Rabbits
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Antineoplastic Agents, Phytogenic
  • Prodrugs
  • Irinotecan
  • CPT-11 converting enzyme
  • Carboxylic Ester Hydrolases
  • Carboxylesterase
  • Camptothecin