A whole genome association study in multiple sclerosis patients from north Portugal

J Neuroimmunol. 2003 Oct;143(1-2):116-9. doi: 10.1016/j.jneuroim.2003.08.024.

Abstract

Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Aged
  • Case-Control Studies
  • DNA / blood
  • Electrophoresis, Capillary
  • Female
  • Genetic Predisposition to Disease*
  • Genetic Testing / methods*
  • Genetic Testing / statistics & numerical data
  • Genetics, Population
  • Genome, Human*
  • Humans
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Polymerase Chain Reaction
  • Portugal / epidemiology

Substances

  • DNA