Dopamine receptor D2 -141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia

Psychiatry Res. 2003 Nov 1;121(1):89-92. doi: 10.1016/s0165-1781(03)00201-4.

Abstract

We examined the occurrence of the -141C Ins/Del polymorphism in 93 Finnish patients with schizophrenia. In comparison with previous studies with Japanese and Caucasian populations, the incidence of this polymorphism was unexpectedly low. The findings suggest that the frequency of the -141C Ins/Del polymorphism is lower in Northern Europe compared to other Caucasian and Japanese populations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Chromosome Deletion*
  • Cross-Cultural Comparison
  • Cytosine / metabolism*
  • Europe
  • Finland
  • Gene Frequency / genetics
  • Genetics, Population
  • Genotype
  • Humans
  • Japan
  • Mutagenesis, Insertional*
  • Odds Ratio
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics
  • Receptors, Dopamine D2 / genetics*
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*

Substances

  • Receptors, Dopamine D2
  • Cytosine