Biodegradable electrospun fibers for drug delivery

J Control Release. 2003 Oct 30;92(3):227-31. doi: 10.1016/s0168-3659(03)00372-9.

Abstract

The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biodegradation, Environmental
  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / chemistry
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism
  • Drug Delivery Systems / methods*
  • Endopeptidase K / metabolism
  • Hydrophobic and Hydrophilic Interactions
  • Lactic Acid / chemistry*
  • Lactic Acid / metabolism
  • Microscopy, Electron, Scanning
  • Nanotechnology / methods
  • Paclitaxel / administration & dosage
  • Paclitaxel / chemistry
  • Polyesters
  • Polymers / chemistry*
  • Polymers / metabolism
  • Rifampin / administration & dosage
  • Rifampin / chemistry
  • Sodium Dodecyl Sulfate / chemistry
  • Spectrophotometry, Ultraviolet
  • Static Electricity
  • Surface-Active Agents / chemistry

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • Polyesters
  • Polymers
  • Surface-Active Agents
  • Lactic Acid
  • Sodium Dodecyl Sulfate
  • poly(lactide)
  • Doxorubicin
  • Endopeptidase K
  • Paclitaxel
  • Rifampin