R2D2 leads the silencing trigger to mRNA's death star

Cell. 2003 Oct 17;115(2):132-3. doi: 10.1016/s0092-8674(03)00806-7.

Abstract

During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.

MeSH terms

  • Animals
  • Cells, Cultured
  • Drosophila / cytology
  • Drosophila / genetics
  • Drosophila / metabolism
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Gene Silencing
  • RNA Interference*
  • RNA, Messenger / metabolism
  • RNA, Small Interfering / biosynthesis
  • RNA, Small Interfering / metabolism
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Ribonuclease III / metabolism

Substances

  • Drosophila Proteins
  • R2D2 protein, Drosophila
  • RNA, Messenger
  • RNA, Small Interfering
  • RNA-Binding Proteins
  • Ribonuclease III