Presence of key drug resistance mutations in isolates from untreated patients of Abidjan, Côte d'Ivoire: ANRS 1257 study

AIDS Res Hum Retroviruses. 2003 Aug;19(8):713-7. doi: 10.1089/088922203322280946.

Abstract

A total of 107 HIV-1 isolates from untreated adult patients recruited in Abidjan, CMte d'Ivoire, in 2001 and 2002 were sequenced in the env, reverse transcriptase (RT), and protease genes. The results show that CRF02_AG is still predominant in this west African population; key mutations of resistance to antiretroviral drugs (NRTI, NNRTI, and PIs) were detected in 5.6% of the patients. We hypothesize that these resistant mutants have been acquired through horizontal transmission. Compared to a previous study carried out by our group in 1997-2000 in a similar population of Abidjan, it seems that there is a dynamic process of resistance and that a survey will be necessary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / pharmacology
  • Cote d'Ivoire / epidemiology
  • DNA, Viral / analysis
  • Drug Resistance, Viral / genetics*
  • Female
  • Gene Transfer, Horizontal
  • Genetics, Population
  • HIV Infections / drug therapy
  • HIV Protease / genetics*
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / classification
  • HIV-1 / drug effects
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mutation

Substances

  • Anti-HIV Agents
  • DNA, Viral
  • HIV Reverse Transcriptase
  • HIV Protease