Cellular generators of the cortical auditory evoked potential initial component

Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):196-200. doi: 10.1016/0168-5597(92)90026-8.

Abstract

Cellular generators of the initial cortical auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Cerebral Cortex / physiology*
  • Electroencephalography
  • Evoked Potentials, Auditory / physiology*
  • Macaca fascicularis
  • Male