Muscle siderosis in AIDS: a marker for macrophage dysfunction?

J Neurol. 1992 Jan;239(1):46-8. doi: 10.1007/BF00839212.

Abstract

We have observed numerous iron granules in muscle fibres, endothelial cells and macrophages of muscle biopsy specimens of 21 out of 41 AIDS patients with different patterns of muscle involvement. All patients were severely immunodepressed. We report on our findings and discuss the mechanism of muscle siderosis that may point to deterioration of some functions of macrophages at a late stage of HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / pathology
  • Biopsy
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / pathology
  • Cytoplasmic Granules / chemistry
  • Humans
  • Iron / analysis*
  • Macrophages / chemistry
  • Macrophages / pathology*
  • Muscles / chemistry
  • Muscles / pathology
  • Muscular Diseases / complications*
  • Muscular Diseases / pathology
  • Peripheral Nervous System Diseases / complications
  • Peripheral Nervous System Diseases / pathology
  • Siderosis / complications*
  • Siderosis / pathology
  • Staining and Labeling

Substances

  • Iron