Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

N G Copeland; D J Gilbert; M Chrétien; N G Seidah; N A Jenkins

doi:10.1016/0888-7543(92)90069-5

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

Genomics. 1992 Aug;13(4):1356-8. doi: 10.1016/0888-7543(92)90069-5.

Authors

N G Copeland¹, D J Gilbert, M Chrétien, N G Seidah, N A Jenkins

Affiliation

¹ Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702.

PMID: 1354647
DOI: 10.1016/0888-7543(92)90069-5

Abstract

The genes for three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), have been regionally localized on chromosomes 13, 2, and 7, respectively, by interspecific backcross analysis. These results refine previous localizations by in situ hybridization as well as confirm and extend known regions of homology between mouse and human chromosomes.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Chromosome Mapping*
Crosses, Genetic
Furin
Mice
Mice, Inbred C57BL
Polymorphism, Restriction Fragment Length
Subtilisins / genetics*

Substances

Subtilisins
Furin

Grants and funding

N01-C0-74101/PHS HHS/United States