The most frequent cause of death of patients with multiple injuries are infectious complications developing on the basis of secondary posttraumatic immunodeficiency syndrome. The authors submit their experience with monitoring of some immunological parameters of these patients and with the use of immunomodulation therapy with transfer factor--a leucocyte dialysate (TF, DLE, Immodin Sevac). They discuss problems pertaining to the mode of therapy, amounts and time of immunomodulation treatment in these patients.