Microenvironment analysis and identification of magnesium binding sites in RNA

Nucleic Acids Res. 2003 Aug 1;31(15):4450-60. doi: 10.1093/nar/gkg471.

Abstract

Interactions with magnesium (Mg2+) ions are essential for RNA folding and function. The locations and function of bound Mg2+ ions are difficult to characterize both experimentally and computationally. In particular, the P456 domain of the Tetrahymena thermophila group I intron, and a 58 nt 23s rRNA from Escherichia coli have been important systems for studying the role of Mg2+ binding in RNA, but characteristics of all the binding sites remain unclear. We therefore investigated the Mg2+ binding capabilities of these RNA systems using a computational approach to identify and further characterize their Mg2+ binding sites. The approach is based on the FEATURE algorithm, reported previously for microenvironment analysis of protein functional sites. We have determined novel physicochemical descriptions of site-bound and diffusely bound Mg2+ ions in RNA that are useful for prediction. Electrostatic calculations using the Non-Linear Poisson Boltzmann (NLPB) equation provided further evidence for the locations of site-bound ions. We confirmed the locations of experimentally determined sites and further differentiated between classes of ion binding. We also identified potentially important, high scoring sites in the group I intron that are not currently annotated as Mg2+ binding sites. We note their potential function and believe they deserve experimental follow-up.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Binding Sites
  • Computational Biology
  • Genomics / methods
  • Introns
  • Magnesium / chemistry
  • Magnesium / metabolism*
  • Models, Molecular
  • Models, Statistical
  • Nucleic Acid Conformation
  • RNA / chemistry*
  • RNA / metabolism*
  • RNA, Ribosomal, 23S / chemistry
  • RNA, Ribosomal, 23S / metabolism
  • Static Electricity
  • Tetrahymena / genetics

Substances

  • RNA, Ribosomal, 23S
  • RNA
  • Magnesium