Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies

Am J Cardiol. 2003 Aug 1;92(3):285-8. doi: 10.1016/s0002-9149(03)00626-x.

Abstract

In clinical practice, we found no significant difference between atorvastatin therapy or other statin therapies in the clinical outcomes of patients with acute coronary syndromes receiving clopidogrel therapy. In patients receiving atorvastatin therapy, clopidogrel therapy was associated with a significant decrease in mortality and stroke during univariate analysis and a moderate trend of reduced mortality and stroke without statistical significance in the multivariate analysis.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aged
  • Atorvastatin
  • Clopidogrel
  • Comorbidity
  • Coronary Disease / drug therapy*
  • Coronary Disease / mortality
  • Drug Interactions
  • Drug Utilization / statistics & numerical data
  • Female
  • Germany / epidemiology
  • Heptanoic Acids / therapeutic use*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyrroles / therapeutic use*
  • Registries / statistics & numerical data
  • Stroke / epidemiology
  • Survival Analysis
  • Syndrome
  • Ticlopidine / analogs & derivatives
  • Ticlopidine / therapeutic use*
  • Treatment Outcome

Substances

  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Atorvastatin
  • Clopidogrel
  • Ticlopidine