A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5

Cold Spring Harb Symp Quant Biol. 2002:67:317-25. doi: 10.1101/sqb.2002.67.317.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Arrhythmias, Cardiac / genetics*
  • Arrhythmias, Cardiac / physiopathology
  • Disease Models, Animal
  • Electrophysiology
  • Heart Septal Defects, Atrial / genetics*
  • Heart Septal Defects, Atrial / physiopathology
  • Heterozygote
  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Humans
  • In Vitro Techniques
  • Mice
  • Mice, Mutant Strains
  • Myocytes, Cardiac / metabolism
  • Patch-Clamp Techniques
  • Potassium / metabolism
  • Tachycardia, Ventricular / genetics
  • Tachycardia, Ventricular / physiopathology
  • Transcription Factors*
  • Xenopus Proteins*

Substances

  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins
  • NKX2-5 protein, human
  • Nkx2-5 protein, mouse
  • Transcription Factors
  • Xenopus Proteins
  • Potassium