Abstract
The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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BCG Vaccine / immunology
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Lysine / metabolism*
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Mice
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Mice, Inbred C57BL
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / metabolism*
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Tuberculosis Vaccines / immunology*
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Vaccination
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Vaccines, Attenuated / immunology
Substances
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BCG Vaccine
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Tuberculosis Vaccines
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Vaccines, Attenuated
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Lysine