Abstract
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified by modification of the substituents at the D-ring.
MeSH terms
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Animals
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Cell Line
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Chlorocebus aethiops
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Humans
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Inhibitory Concentration 50
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Progesterone / pharmacology
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Quinolines / chemical synthesis
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Quinolines / chemistry*
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Quinolines / pharmacology*
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Receptors, Progesterone / agonists
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Receptors, Progesterone / antagonists & inhibitors*
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Receptors, Progesterone / metabolism
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Receptors, Steroid / antagonists & inhibitors
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Structure-Activity Relationship
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Transcription, Genetic / drug effects
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Transfection
Substances
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Quinolines
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Receptors, Progesterone
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Receptors, Steroid
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Progesterone