Objective: To study the effect of satragaloside IV on the microvascular permeability induced by histamine in pial microvessels.
Method: The microvascular permeability was expressed by changes in the transendothelial electrical resistance which was measured with technique using microelectrode impaled into the vascular lumen and based on cable analysis of vessels in rat.
Result: The transendothelial electrical resistance of microvessels superfused with artificial cerebrospinal fluid was about 2500 omega.cm2, indicating a tight barrier with extremely low ion permeability, and application of 10(-4) mol.L-1 histamine in superfusate caused a rapid and reversible decrease in transendothelial electrical resistance. In paired experiment, the decrease of transendothelial electrical resistance induced by 10(-4) mol.L-1 histamine was inhibited by adding 0.8 x 10(-4) mol.L-1 satragaloside IV in superfusate.
Conclusion: The results indicated that increases in the microvascular permeability induced by histamine, and satragaloside IV can inhibit the increases in the microvascular permeability induced by histamine. It is necessary that the cellular mechanism of permeability response induced by satragaloside IV be further elucidated.