Pachyclavulariolides M-R, six novel diterpenoids from a Taiwanese soft coral Pachyclavularia violacea

J Nat Prod. 2003 May;66(5):662-6. doi: 10.1021/np020603j.

Abstract

Six novel diterpenoids, pachyclavulariolides M-R (1-6), have been isolated from a Taiwanese soft coral Pachyclavularia violacea. The structures and relative stereochemistry of compounds 1-6 were established by spectroscopic analyses. Compound 1 has been shown to exhibit significant cytotoxicity toward P-388 cancer cells. Biosynthesis of 4-6 is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Colonic Neoplasms
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • KB Cells / drug effects
  • Leukemia P388
  • Lung Neoplasms
  • Mice
  • Molecular Structure
  • Taiwan
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Diterpenes