Abstract
The pancreaticoduodenal disease in Multiple endocrine neoplasia type 1 (MEN1) is the most frequent cause of death due to the syndrome, and the most controversial with regard to its management. This article discusses the current data and recommendations with respect to disease screening, functional tumour diagnosis, natural history, preoperative imaging, operative strategy and follow-up.
MeSH terms
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Aged
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Carcinoma, Islet Cell / diagnosis*
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Carcinoma, Islet Cell / mortality
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Carcinoma, Islet Cell / surgery
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Duodenal Neoplasms / diagnosis*
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Duodenal Neoplasms / mortality
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Duodenal Neoplasms / surgery
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Endosonography
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Female
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Gastrinoma / diagnosis
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Gastrinoma / mortality
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Gastrinoma / surgery
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Genetic Testing / methods
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Heterozygote
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Humans
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Male
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Middle Aged
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Multiple Endocrine Neoplasia Type 1 / diagnosis*
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Multiple Endocrine Neoplasia Type 1 / mortality
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Multiple Endocrine Neoplasia Type 1 / surgery
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Pancreatic Hormones / blood
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Pancreatic Neoplasms / diagnosis*
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Pancreatic Neoplasms / mortality
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Pancreatic Neoplasms / surgery
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Postoperative Care
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Tomography, X-Ray Computed