This is the first report of the observation of pancreas cancer with an autofluorescence endoscopic imaging system (excitation: 437 nm). A case of intraductal papillary adenocarcinoma of pancreas was presented. After pancreatectomy, the resected pancreas was used to test the endoscope (16Fr) in the pancreatic duct. The normal pancreatic duct was seen as light blue and the protruding cancerous lesion was observed as a dark red image. In previous studies, cancerous lesions of the gastrointestinal tract, bronchial tree and bile duct also appeared dark red when examined by autofluorescence endoscopy. In the pancreatic duct, the cancer lesion was also detected as dark red color.